Effect of Shenqi Jiangtang Granule on atherosclerotic changes of lower extremities in patients with early type 2 diabetes mellitus

VernacularTitle:参芪降糖颗粒对2型糖尿病早期下肢动脉粥样硬化性病变的影响
Author: Yiwei ZHOU ; Jianhua GUO ; Changsong MA ; Jie SUN
Publication Type:Journal Article
Keywords: Shenqi Jiangtang granule; Type2 diabetes mellitus; Atherosclerotic disease of lower extremitias; Atherosclerosis
From: International Journal of Traditional Chinese Medicine 2010;32(2):142-143
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of Shenqi Jiangtang granule (SJG) on atherosclerotic disease (LEAD) of lower extremity in patients with early type 2 diabetes mellitus (T2DM). Methods The patients were randomly assigned to a control group and a treatment group. 30 patients in the treatment group were treated by SJG and 30 patients in the control group were given Cilostazo. Both groups were treated for 3 months. Lower extremity vascular color Doppler image, blood levels of interleukin-6 (IL-6) were measured before and after the treatment. Results The thickness of atherosclerosis (AS) plaque and arterial media were obviously reduced (t=3.376, 3.468, P<0.05) , serum levels of IL-6 were also be lowered obviously (t=3.345, P<0.05) in the treatment group. While these indexes remained unchanged in the control group. Conclusion SJG has remarkable action in reducing the thickness of AS plaque and media of artery. The mechanism might be related with its reducing serum IL-6 level.