Pay more attention to the study of the relationship between diabetes mellitus and cancer
10.3760/cma.j.issn.1000-6699.2010.03.001
- VernacularTitle:重视糖尿病与癌症关系的研究
- Author:
Jiaqing ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Cancer;
Insulin;
Insulin-like growth factors;
Insulin analogues;
Metformin
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(3):177-180
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic patients are at increased risk of some cancers,mainly pancreatic cancer,liver cancer,colorectal cancer,breast cancer,endometrial cancer,etc.,and these cancers often result in higher mortalities than that in nondiabetics.The exact mechanism of this relationship is still unclear.The most suggested factor are hyperinsulinemia and insulin-like growth factors with their growth promoting and mitogenic effects.Recently,some insulin analogues are suspected to have these carcinogenic effects,but no firmly proven data are available yet.Metformin may have a protective effect in this regard.
