Efficacy of tea polyphenols in inhibiting inflammatory damage to islet beta cell of rats with metabolic syndrome
10.3760/cma.j.issn.1000-6699.2010.03.016
- VernacularTitle:茶多酚减轻代谢综合征大鼠胰岛β细胞炎性损伤的机制研究
- Author:
Yanping XIA
;
Gang CHEN
;
Maohua YU
- Publication Type:Journal Article
- Keywords:
Tea polyphenols;
Metabolic syndrome;
Islet β-cell
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(3):229-231
- CountryChina
- Language:Chinese
-
Abstract:
A rat model of metabolic syndrome was induced by high glucose plus high fat diet and treated by tea polyphenols for 10 weeks.The results showed that the levels of fasting blood glucose,triglyceride,cholesterol,low-density lipoprotein cholesterol,and free fatty acid in tea polyphenols treatment group were significantly lower than those in control group(all P＜0.05),along with decreased TNF-α,IFN-γ,iNOS mRNA and protein expressions,and IL-1β protein expression in pancreatictissue (all P＜0.05).Under electron microscope,more secretory granules in islet beta cells and impoveddisorganization of cellular organ were shown in tea polyphenols treatment group compared with metabolic syndrome group.The results suggest that tea polyphenols are able to protect islet β cells against oxidative damage via inhibiting the production of inflammatory cytokines.
