Effect of adiponectin on the levels of serum CRP and sICAM-1 in type 2 diabetic rats
10.3760/cma.j.issn.1000-6699.2010.03.017
- VernacularTitle:脂联素对2型糖尿病大鼠循环CRP及sICAM-1水平的影响
- Author:
Jinbo LIU
;
Huacong DENG
;
Bingrong LI
;
Lizhen LAN
;
Hongting ZHENG
;
Fuyuan ZHUGE
;
Zhimei Lü
- Publication Type:Journal Article
- Keywords:
Adiponectin;
C-reactive protein;
Soluble intercellular adhesion molecule-1;
Diabetes mellitus
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(3):232-234
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetic rats were treated with recombiriant adenovirus expressing human adiponectin (Ad-APN).The results showed that the levels of both plasma C-reactive protein and soluble intercellular adhesion molecule-1 were significantly decreased in Ad-APN-treated diabetic rats compared with those of diabetic rats [(18.73±4.66 vs 23.60±4.25)mg/L and (14.91±1.79 vs 19.09±2.95) ng/ml,both P＜0.01].These results suggest that increased serum concentration of adiponectin may improve the status of inflammation in diabetes mellitus.
