Effects of cyclosporine A on the expressions of MMP-2 and MMP-9 in the heart of streptozocin-induced diabetic rats
10.3760/cma.j.issn.1000-6699.2010.03.019
- VernacularTitle:环孢素A对链脲菌素诱导糖尿病大鼠心脏MMP-2和MMP-9表达的影响
- Author:
Jin CUI
;
Deqiang LI
;
Mingcai QIU
;
Peng ZHANG
;
Xin ZHANG
;
Jinshi ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Diabetic cardiomyopathy;
Matrix metalloproteinases;
Cyclosporine A
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(3):238-240
- CountryChina
- Language:Chinese
-
Abstract:
The effects of cyclosporine A on matrix metalloproteinases(MMP)-2 and-9 expressions in the cardiac muscle of streptozocin-induced diabetic rats were investigated.The expressions of MMP-2 and MMP-9 mRNA and proteins in the cardiac muscle of diabetic rats were significantly upregulated,which could be decreasedby cyclosporine A(P＜0.05 or P＜0.01).The results suggest that cyclosporine A may effectively ameliorate the injuries of diabetic cardiomyopathy.
