Molecular Mechanisms Governing IL-24 Gene Expression.
- Author:
Anupama SAHOO
1
;
Sin Hyeog IM
Author Information
- Publication Type:Review
- Keywords: IL-24; Chromatin remodeling; Epigenetics; Transcription factor; Gene regulation
- MeSH: Arthritis, Rheumatoid; Autoimmune Diseases; Chromatin Assembly and Disassembly; Cytokines; Epigenomics; Gene Expression; Humans; Interleukin-10; Interleukins; Lung; Psoriasis; Signal Transduction; Skin; Transcription Factors
- From:Immune Network 2012;12(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: Interleukin-24 (IL-24) belongs to the IL-10 family of cytokines and is well known for its tumor suppressor activity. This cytokine is released by both immune and nonimmune cells and acts on non-hematopoietic tissues such as skin, lung and reproductive tissues. Apart from its ubiquitous tumor suppressor function, IL-24 is also known to be involved in the immunopathology of autoimmune diseases like psoriasis and rheumatoid arthritis. Although the cellular sources and functions of IL-24 are being increasingly investigated, the molecular mechanisms of IL-24 gene expression at the levels of signal transduction, epigenetics and transcription factor binding are still unclear. Understanding the specific molecular events that regulate the production of IL-24 will help to answer the remaining questions that are important for the design of new strategies of immune intervention involving IL-24. Herein, we briefly review the signaling pathways and transcription factors that facilitate, induce, or repress production of this cytokine along with the cellular sources and functions of IL-24.
