Effect of glucose on hormone sensitive lipase in NTT-1 cell
10.3760/cma.j.issn.1000-6699.2010.03.018
- VernacularTitle:葡萄糖对NIT-1细胞激素敏感性脂肪酶的影响
- Author:
Yongbo WANG
;
Lulu CHEN
;
Yon LI
;
Yuan TIAN
- Publication Type:Journal Article
- Keywords:
Glucose;
Islet β cell;
Hormone sensitive lipase;
Triglyceride
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(3):235-237
- CountryChina
- Language:Chinese
-
Abstract:
NIT-1 cells were exposed to various concentrations of glucose for 24,48,and 72 hours.The content of triglyceride in NIT-1 cells increased in dose-and time-dependent manners (P ＜ 0.05).Long-term exposure of NIT-1 cells to high glucose concentrations caused an inverse "v"-like induction of HSL mRNA and protein expressions,which increased from beginning,and then decreased,along with similar changes of lipolysis.These results suggest that the adaptation of HSL may play an important role in regulating the intracellular triglyceride pool and the development of glucolipotoxicity in pancreatic β cells.
