The change of CD4~+ CD25~+ regulatory T cells after the transplant neplwedamy in human renal redipients with chronic allograft nephropathy
10.3760/cma.j.issn.0254-1785.2010.03.012
- VernacularTitle:慢性移植肾肾病所致功能丧失移植肾切除与否对CD4~+CD25~+Treg细胞的影响
- Author:
Chuanfu DU
;
Lizin YU
;
Shaojie FU
;
Jian XU
;
Wenfeng DENG
;
Yibin WANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Transplants;
Kidney failure,chronic;
Nephreetomy;
T-lymphocytes
- From:
Chinese Journal of Organ Transplantation
2010;31(3):177-180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the change of the CD4~+ CD25~+ Treg after the transplant nephrectomy in recipients suffering from chronic allograft nephropathy (CAN) with normal PRA level.Methods Thirty recipients suffering from CAN,aged 20-55 years old,with norlTlal PRA level,were divided into two groups:removal group (n=17) and preserving group(n=13).CD4~+ CD25~(high)/CD4~+,CTLA-4 and Foxp3 in peripheral blood were tested at two time ends:O month and 2 months after the transplant nephrectomy operation.Results (1) Ratio of CD4~+ CD25~(high)/CD4~+ at the Oth and 2nd month in the removal group was(1.47±0.19)%,(1.08±0.16)%,and that was(1.44±0.25)% and (1.77±0.24)%,at the same time in the preserving group (P<0.01).(2) The expression of CTLA-4 at the Oth and 2nd month in the removal group was (76.82±5.31)% and (72.56±4.99)%,and that was (76.20±4.22)% and (75.24±4.26)% in the preserving group (P>0.05).(3)The expression of Foxp3 was (79.77±1.59)% and (69.07±4.37)% in the removal group,and that was (79.56±1.75)% and (79.09±2.05)% in the preserving group.The expression rate of Foxp3 at the 2nd month in the removal group was significantly lower than in the preserving group (P<0.01).Conclusion Remoral of the graft can reduce the ratio of CD4~+ CD25~(high)/CD4~+ and the expression of Foxp3,suggesting that the removal of the renal graft may inhibit the activity of CD4~+ CD25~+ Treg.
