Establishment of animal model of superior mesenteric vein-portal vein thrombosis
10.3760/cma.j.issn.1673-9752.2009.06.024
- VernacularTitle:肠系膜上静脉-门静脉血栓动物模型的建立
- Author:
Peng SONG
;
Maoqiang WANG
;
Liuxin DUAN
;
Qiang LI
;
Feng DUAN
;
Fengyong LIU
;
Zhijun WANG
;
Fangguang LI
- Publication Type:Journal Article
- Keywords:
Portal vein thrombosis;
Superior mesenteric venous thrombosis;
Animal model
- From:
Chinese Journal of Digestive Surgery
2009;8(6):463-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the feasibility of interventional techniques in the establishment of animal model of superior mesenteric vein-portal vein (SMV-PV) thrombosis. Methods Nine miniature pigs were involved in the study including one for preliminary experiment. After general anesthesia, a balloon catheter was placed in the main trunk of PV to block the portal flow and then thrombin or autologous blood clot was injected to the SMV. Venography was performed to confirm the thrombosis 30 minutes later. Changes in the imaging before and after the thrombosis were observed. Pigs died during the experiment were anatomized to analyze the causes, and pathological examination was performed when necessary. Results The model of SMV-PV thrombosis was successfully established in all the pigs. One pig died of diffuse intravascular coagulation 10 minutes after model establishment in the preliminary experiment. Two pigs died of hepatorrhexis and over dose of anesthetics respec-tively 3 hours after model establishment, and the rest 6 pigs were fed for 14 days. Conclusion Interventional techniques are effective in the establishment of SMV-PV thrombosis model.
