Evaluation of the effect of ilaprazole on intragastrtc pH in patients with duodenal ulcer
10.3760/cma.j.issn.0578-1426.2010.04.006
- VernacularTitle:艾普拉唑对十二指肠溃疡患者胃内pH值的影响
- Author:
Liya ZHOU
;
Sanren LIN
;
Yunsheng YANG
;
Shutian ZHANG
;
Yaozong YUAN
;
Ruihua SHI
;
Xiaohua HOU
;
Jielai XIA
;
Haitang HU
;
Xianghong QIN
- Publication Type:Journal Article
- Keywords:
Duodenal ulcer;
Ilaprazole;
Intragastric pH
- From:
Chinese Journal of Internal Medicine
2010;49(4):290-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of ilaprazole enteric tablets on intragastric pH in duodenal ulcer patients. Methods A randomized, double blind, positive controlled clinical trial was carried out. A total of forty-two patients with duodenal ulcer were randomized into low dose ilaprazole group (5 mg/d), medium dose ilaprazole group (10 mg/d), high dose ilaprazole group(20 mg/d) and omeprazole group(20 mg/d). An ambulatory 24 hour intragastric pH study was performed at the fifth treatment day. Fraction time pH above 3, 4 or 5, median values of 24 hour diurnal pH and 12 hour nocturnal pH, the percentage of patients with total time pH above 3, 4 or 5 at least for 18 hours were evaluated. Results There were no significant differences of fraction time pH above 3 or 4, median values of 24 hour diurnal pH and 12 hour nocturnal pH and the percentage of patients with total time pH above 3, 4 or 5 at least for 18 hours among all the groups with different doses of ilaprazole and the omeprazole group. The fraction time pH above 5 in medium and high dose ilaprazole groups were (87.96 ± 12. 29)% and (89.86±15. 18)% respectively, which was higher than that in low dose ilaprazole group [(67. 17± 30. 16)%] and omeprazole group[(76. 14 ± 16. 75)%], P <0. 05. Conclusion Ilaprazole has a strong effect on intragastric acid control with a dose dependent trend.
