Central Venous Catheter-Related Microbacterium Bacteremia Identified by 16S ribosomal RNA Gene Sequencing.
10.5145/KJCM.2009.12.2.97
- Author:
Chang Jin MOON
1
;
Jong Hee SHIN
;
Eun Sun JEONG
;
Seung Jung KEE
;
Soo Hyun KIM
;
Myung Geun SHIN
;
Soon Pal SUH
;
Dong Wook RYANG
Author Information
1. Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea. shinjh@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
16S rRNA sequencing;
Catheter-related bacteremia;
Microbacterium species
- MeSH:
Adolescent;
Bacteremia;
Brevibacterium;
Central Venous Catheters;
Genes, rRNA;
Humans;
Micrococcus;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Rhodococcus;
RNA, Ribosomal, 16S;
Teicoplanin
- From:Korean Journal of Clinical Microbiology
2009;12(2):97-101
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We describe here a case of central venous catheter (CVC)-related bacteremia caused by Microbacterium species in a 14-year-old patient, who had received chemotherapy for acute lymphoblastic leukemia. All nine blood cultures obtained from admission day 2 to day 62 yielded the same yellow-pigmented coryneform rod. Both Vitek 2 (bioMerieux, USA) and MicroScan (Dade Behring, USA) identified the isolate as Micrococcus species, and the API Coryne (bioMerieux, France) identified the isolate as Rhodococcus or Brevibacterium species. However, the 16S rRNA gene sequence showed a 99% identity with Microbacterium species. The bacteremia was recurrent or persistent over 60 days despite alternate systemic antibiotic therapy, but blood culture became negative after an addition of teicoplanin lock therapy for eradicating CVC-related bacteremia. This represents the first report of CVC-related Microbacterium bacteremia cured by antibiotic lock therapy in Korea.
