Diagnosis and treatment of hepatic veno-occlusive disease induced by sedum aizoon in HBsAg positive patients
10.3760/cma.j.issn.1674-2397.2010.02.004
- VernacularTitle:土三七致HBsAg阳性患者肝小静脉闭塞病的诊断和治疗
- Author:
Huazhong CHEN
;
Milian DONG
;
Hui SHAO
;
Zhiqin ZHANG
;
Jiansheng ZHU
;
Meifu GAN
;
Bing RUAN
- Publication Type:Journal Article
- Keywords:
Hepatic veno-occlusive disease;
Sedum aizoon;
Drug-induced liver disease
- From:
Chinese Journal of Clinical Infectious Diseases
2010;3(2):76-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the diagnosis and treatment of hepatic veno-occlusive disease(HVOD)induced by sedum aizoon in HBsAg positive patients. Methods Clinical data of 35 HBsAg positive cases who took sedum aizoon decoction and developed HVOD were collected, the clinical manifestation, imaging examination, histological examination of liver puncture biopsy, and the outcomes of patients were reviewed. Results Hepatomegaly, liver dysfunction, abdominal effusion and map-like density changes in liver CT scan were observed in 35 patients. Liver biopsy wag performed in 17 patients. In histopathological examination, the swelling and point-like necrosis of liver cells, expansion and congestion of sinus, endothelial swelling, wall thickening, incomplete lumen occlusion of small liver vascular were observed. Map-like density changes in liver CT scan were found in all 17 patients who were diagnosed by histological examination. Fifteen patients presented small amount of ascites within 4 weeks of onset, 13 of whom recovered or improved after treated with low-molecular weight heparin and albumin; while among the remaining 20 patients. only half of them were benefited from the same treatments. Conclusion HVOD can be diagnosed by liver CT scan instead of histological examination; treatment of patients in early stage may improve the outcome.
