Expression of integrin α6 mRNA in skin lesions of patients with condyloma acuminata

VernacularTitle:整合素α6 mRNA在尖锐湿疣患者皮损中的表达
Author: Wujian KE ; Jing CHEN ; Yuanjun LIU ; Weifeng YAO ; Yumin YANG ; Xin ZHENG ; Yamin CHE
Publication Type:Journal Article
Keywords: Human papillomavirus; Condyloma acuminata; Integrin α6
From: Chinese Journal of Clinical Infectious Diseases 2010;3(2):97-99
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of integrin α6 mRNA in skin lesions of patients with condyloma acuminata. Methods Sixty outpatients with condyloma acuminate, including 30 primary cases and 30 recurrent cases were enrolled in the study;30 non-condyloma acuminate patients undergoing circumcision were used as normal controls. The expression of integrin α6 mRNA in condyloma acuminata lesions of primary and recurrent cases, as well as in skin samples of normal controls were determined by RTPCR. ANOVA was used to compare the differences among the groups, and Student-Newman-Keuls test(q test)was used for pairwise comparisons. Results Relative contents of integrin α6 mRNA(integrin α6/GAPDH)in normal controls, primary and recurrent condyloma acuminata lesions were 0.25±0.10, 0.79±0.16 and 1.07±0.29, respectively, and the difference was of statistical significance(F=127.687, P=0.001). Conclusion Integrin α6 may be associated with the pathogenesis and recurrence of condyloma acuminate, which may provide a new target for prevention and treatment of the disease.