Prognostic factors of patients with locally recurrent rectal cancer after radical resection
10.3760/cma.j.issn.1004-4221.2010.03.014
- VernacularTitle:根治术后局部复发性直肠癌的预后因素分析
- Author:
Xiaobin LIU
;
Zhiyong YUAN
;
Jinqiang YOU
;
Bailin ZHANG
;
Li ZHU
;
Peng ZHAO
;
Jianzhong LIU
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms,recurrence/radiotherapy;
Rectal neoplasms,recurrence/ chemotherapy;
Prognosis analysis
- From:
Chinese Journal of Radiation Oncology
2010;19(3):223-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic factors and the clinical outcome of locally recurrent rectal cancer after radical resection. Methods From April 2000 to April 2004, 105 patients with locally recurrent rectal cancer after radical resection were re-treated in Tianjin cancer hospital. Thirty-four patients were re-treated with surgery combined with adjuvant chemoradiotherapy (group 1), 35 with surgery alone (group 2), and 36 with chemoradiotherapy (group 3). The impact of 17 clinicopathological factors and treatment modalities on the survival was analyzed. Results The follow-up rate was 95. 2%. The median survival time was 23 months. The 1-, 3-and 5-year survival rates of patients with locally recurrent rectal cancer were 63% ,34% and 19%, respectively. The 1-, 3-and 5-year survival rates were 79%, 55% and 32% in group 1 ; 68%, 40% and 14% in group 2; and 64%, 36% and 11% in group 3; respectively (χ~2 =7. 96,P =0. 019). The univariate analysis showed that the degree of differentiation, depth of tumor invasion, number of metastatic lymph nodes, initial TNM stage, recurrent location, time to recurrence, and surgery combined with adjuvant therapy were significant prognostic factors, with the last 4 being the independent prognostic factors. Conclusions Surgery combined with chemoradiotherapy may improve the survival of patients with locally recurrent rectal cancer.
