Serum levels of triggering receptor expressed on myeloid cells-1 and inflammatory factors in patients with acute pancreatitis and its clinical values
10.3760/cma.j.issn.1674-1935.2010.02.006
- VernacularTitle:急性胰腺炎患者血清髓系细胞触发受体-1水平及其临床应用价值
- Author:
Shaobi ZHOU
;
Huasheng LIANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Myeloid cells;
Chemokines
- From:
Chinese Journal of Pancreatology
2010;10(2):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the serum levels of triggering receptor expressed on myeloid cells-1 (TREM-1), analyse its relationship with inflammatory factors, and explore its clinical values. Methods Serum concentrations of TREM-1, TNF-α, IL-8 and IL-1β in 19 patients with early acute pancreatitis (AP) were measured by enzyme-linked immunoadsorbent assay and the relationship among them was analyzed, and it was compared with those of 20 normal controls. Results In patients with early AP, serum levels of TNF-α, IL-8, IL-1β and TREM-1 were (52.26±12.98) pg/ml, (20.18±9.81) pg/ml, (35.57 ± 13.34) pg/ml and (83.09 ± 32.49) pg/ml;while they were (18.69 ± 6.42) pg/ml, (9.81 ± 4.80) pg/ml, (14.94 ± 5.16) pg/ml and (8.44±8.42) pg/ml in control group, and there was significant difference between the two groups (P < 0.01). TREM-1 was positively correlated with other inflammatory factors in patients with early AP, and it had a sensitivity of 77.8%, specificity of 70.0% for prognosis prediction, which was better than TNF-α, IL-8, IL-1β. Conclusions TREM-1 may influence the leveLs of inflammatory factors and to some extent predict the early prognosis of AP.