Expression of peroxisome proliferator-activated receptor-γ and angioteusin Ⅱ receptor protein in chronic pancreatitis tissue
10.3760/cma.j.issn.1674-1935.2010.02.013
- VernacularTitle:过氧化物酶体增殖物激活受体-γ和血管紧张素Ⅱ受体在慢性胰腺炎组织中的表达及意义
- Author:
Ling HUANG
;
Jun GAO
;
Xiaohua MAN
;
Yanfang GONG
;
Zhaoshen LI
- Publication Type:Journal Article
- Keywords:
Pancreatitis,chronic;
Peroxisome proliferator-activated receptors;
Angiotensin receptors
- From:
Chinese Journal of Pancreatology
2010;10(2):113-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of peroxisome proliferator-activated receptor-γ(PPAR-γ) and angiotensin receptor (AT2R) in chronic pancreatitis tissue. Methods Between April 2006 and February 2009, 24 patients were pathologically diagnosed as chronic pancreatitis were enrolled and 12 samples of normal pancreatic tissues were treated as controls. Immunohistochemical staining was used to detect PPAR-γ and AT1R, AT2R expression in pancreatic tissues. Results PPAR-γ and AT1R were mostly negatively expressed in normal pancreatic tissues, the positive scores were 0.33±0.49 and 0.42 ± 0. 51, respectively, while AT2R were weakly positively or negatively expressed in acinus and islet cell, and it was weakly positively expressed in ductal epithelial cells, the positive score was 2. 33 ± 1. 37. In chronic pancreatitis tissue, PPAR-γ, AT1R and AT2R were positively expressed in acinus, ductal epithelial cells, and islet cell, the positive scores were 3.28 ± 2.46, 4.36 ± 2.80 and 4.61 ± 2.89, which were significantly higher than those in the normal group (P<0.01, P <0.01, P<0.05). Conclusions PPAR-γ, AT1R and AT2R were positively expressed in chronic pancreatitis tissue, and they may be the treatment target of chronic pancreatitis.
