Regional myocardial function and genetic bases in patients with hypertrophic cardiomyopathy
10.3760/cma.j.issn.1673-4408.2010.03.024
- VernacularTitle:肥厚型心肌病的局部心肌功能变化和分子遗传学基础
- Author:
Yinjia ZHANG
- Publication Type:Journal Article
- Keywords:
Cardiomyopathy,hypertrophic;
Strain;
Gene mutation
- From:
International Journal of Pediatrics
2010;37(3):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Hypertrophic cardiomypathy is a genetically heterogeneous cardiac disease transmitted as an autosomal dominant trait,mostly caused by mutant of myofribrilla gene such as β-MHC, MYBPC3, cTnT.cTnI,cTnC, a-Tm and some other gene which coding non-myofribrilla. Different mutant caused different regional myocardium systolic or diastole function, which involve in dysfunction of systolic and diastolic deformation, increase of the sensitive of Ca2+ . This review summarizes the most common gene mutations in hypertrophic cardiomypathy and explains the changes of myocardial functions.
