Expression of VEGF-C and it's relationship with clinical pathologic characteristics in rectal cancer

VernacularTitle:VEGF-C在直肠癌中的表达与临床病理特征的关系
Author: Tao LIU ; Chao ZHANG ; Wei Lü ; Lu GAN ; Liye LIU ; Hua CHEN ; Yingxue HAO
Publication Type:Journal Article
Keywords: Rectal neoplasms; Pathology; Lymph nodes; VEGF-C; Cytokeratin 20; Micrometastasis
From: Chinese Journal of General Surgery 2010;25(4):306-308
CountryChina
Language:Chinese
Abstract: Objective To study the expression of VEGF-C and it's relationship with pathologic characteristics in rectal cancer.Method In this study 82 patients of mid to low rectal cancer underwent radieal resection from December 2007 to August 2008.Tumor tissues and lymph nodes were studied by immunohistochemical staining for VEGF-C expression in the tumor tissue and CK20 expression in D3 lymph nodes.Results were compared with the pathological results of mesenterium lymph nodes to explain the relationships between VEGF-C expressions and clinical pathologic characteristics.Data were analyzed with Chi square test.Result As for the expression of VEGF-C.significant differences were found between tumor stages(X~2=8.529,P<0.05)and between positive and negative lymph node metastasis(X~2=4.712,P<0.05).but there was no difference between that of mesenterium lymph node metastasis and D3 lymph node micrometastasis(X~2=0.017,P>0.05). Conclmion In rectal cancer,VEGF-C expression is correlated with tumor stage,type,metastasis and micrometastasis of lymph node.