Research progress of the relation of HFA and oarian cancer
10.3760/cma.j.issn.1673-422X.2010.03.020
- VernacularTitle:人附睾分泌蛋白与卵巢癌的关系
- Author:
Jing SUN
- Publication Type:Journal Article
- Keywords:
Ovarian cancer;
Tumor marker,biological;
Epididymal secretory proteins;
Enzyme-linkod immunosorbent Assay
- From:
Journal of International Oncology
2010;37(3):222-225
- CountryChina
- Language:Chinese
-
Abstract:
Human epididymis gene product 4 (HFA)mRNA highly expressed in oarian cancer tissue and the quantity was associated with the type of the ovarian cancer;The serum HF4 had the same specificity and sensitivity in the early diagnosis of oarian cancer compared with CA125 ,and the HF4 had an advantage over theCA125 in that it was less frequently positive in patients with nonmalignant disease;the combination of HE4 andCA125 yielded higher sensitivity ;The serum tumor marker HFA is an excellent marker for determining responseto treatment and for the detection of early recurrence of disease in patients with epithelial ovarian cancer; HE4 isnot only a serological tumor biomarker but also a target for gene-based therapy of ovarian cancer.
