Study on the expression and significance of prostate stem cell antigen in perineural invasion of pancreatic carcinoma

VernacularTitle:前列腺干细胞抗原在人胰腺癌神经浸润转移中作用的研究
Author: Lingxin MENG ; Zhaojun DING ; Xiping CHEN ; Hong ZHANG ; Yuhua CHI ; Fengsong WANG
Publication Type:Journal Article
Keywords: Pancreatic neoplasms; Prostate stem cell antigen
From: Journal of International Oncology 2010;37(3):234-236
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of the expression of prostate stem cell antigen(PSCA)in the development of perineural invasion in pancreatic carcinoma.Methods The histopathologic and immunohis-tochemical(SABC)studies were performed on 80 patients with pancreatic carcinoma.The overall incidence of PSCA expression,perineural,lymphatic and vascular vessel invasion were counted to investigate the relationships among them.Results Perineurel invasion was positively correlated with lymphatic and vascular vessel invasion (P<0.01).A positive corelation Was found between tumor PSCA expressioa(53 cases)and the perineurel in-vasion(66 cases).A definite correlation Was also found between cancer differentiation and PSCA tyxplres-sion.Conclusion PSCA is one of the most important molecules and may play a role as a "navigating" and " docking" molecule in the developmeat of perineural invasion.