Effects of CXCL12-CXCR4 in the invasion and metastasis of pancreatic cancer
10.3760/cma.j.issn.1673-422X.2010.03.019
- VernacularTitle:CXCL12-CXCR4在胰腺癌侵袭转移中的作用
- Author:
Ning ZHAO
- Publication Type:Journal Article
- Keywords:
Chemotactic factors;
Receptors,chemokine;
Pancreatic neoplasms;
Neoplasm invasion;
Neoplasm metastasis
- From:
Journal of International Oncology
2010;37(3):219-222
- CountryChina
- Language:Chinese
-
Abstract:
Recent researches have revealed that the CXCL12/CXCR4 bio-axis is pivotal in the invasion and metastasis of pancreatic cancer. CXCL12/CXCR4 may promote the tumor invasion and metastasis through the mechanism of stimulating the proliferation of cancer cells, enhancing the migration of tumor cells, inducing the extra-cellular matrix degradation and angiogenesis.
