Progress of research on the relations of GST-π and chemotherapy drug resistance for ovarian cancer
10.3760/cma.j.issn.1673-422X.2010.03.021
- VernacularTitle:谷胱甘肽转移酶-π与卵巢癌化疗耐药的关系
- Author:
Meng LIANG
- Publication Type:Journal Article
- Keywords:
Glutathione transferase;
Ovarian neoplasms;
Drug resistance multiple
- From:
Journal of International Oncology
2010;37(3):225-227
- CountryChina
- Language:Chinese
-
Abstract:
The platinum-based chemotherapy play an important role in alleviating symptoms of advanced ovarian cancer patients and prolongation of survival time ,The multidrug resistance(MDR),however,seriously affects the chemotherapy affect, the current MDR and its Mechanism studies show that,as a phase Ⅱ detoxification enzymes ghtathione S-transferase-π(GST-π) promote tumor cell resistance to chemotherapoutic drugs by affecting the biotransformation and metabolic processes of drugs,and closely related to MDR in ovarian cancer.
