Expression and significance of E-cadherin and matrix metallopeptidase 7 in basal-like and Her-2 over-expressing breast carcinoma
10.3760/cma.j.issn.1007-631X.2010.04.016
- VernacularTitle:上皮钙黏蛋白和基质金属蛋白酶-7在乳腺癌基底细胞样型和Her-2高表达型中的表达及其意义
- Author:
Xue GAO
;
Hongwei GUAN
;
Xin CAI
;
Zhinggang SUN
;
Dan CHEN
;
Liju CHEN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Carcinoma,basal cell;
Cadherins;
Matrix metalloproteinase 7
- From:
Chinese Journal of General Surgery
2010;25(4):318-321
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of E-cadherin and matrix metallopeptidase 7(MMP-7)and their significance in basal-like and Her-2 over-expressing breast carcinoma. Methods The protein expression of E-cadherin and MMP-7 were analyzed by immunohistochemical method in 20 cases of basal-like breast carcinoma and 21 cases of Her-2 over-expressing breast carcinoma.Statistical method was used to analyze the clinicopathological performance.Patients were followed up from 6 to 60 months.Results The ratio of basal-like breast carcinoma and invasive ductal carcinoma was 3.4%(20/501).the mean age was 49 years.The mean size of basal-like breast carcinoma(2.1 cm)was smaller than that of Her2 over-expressing breast carcinoma(3.0 cm)(P<0.05).The 5-year survival rate of patients with basal-like breast carcinoma was obviously(40.0%) lower than that of Her-2 over-expressing breast carcinoma (71.4%)(P<0.05),though,the 3-year survival rate was similar between the two groups.The protein expression of E-cadherin was down-regulated and even deficient in basal-like breast carcinoma(P<0.05).The protein expression of MMP-7 was higher in basal-1ike breast carcinoma than that in Her-2 overexpressing breast carcinoma(P<0.05).Conclusion Down-regulated expression of E-cadherin and upregulated expression of MMP-7 may be one of the mechanisms leading to high metastasis of basal-like breast carcinoma.
