The roles of lipoprotein-associated phospholipase A2 in carotid artery atherosclerosis and ischemic stroke
10.3760/cma.j.issn.1673-4165.2010.04.009
- VernacularTitle:脂蛋白相关磷脂酶A2在颈动脉粥样硬化和缺血性卒中中的作用
- Author:
Yuan ZHOU
;
Xiaohui ZHAO
- Publication Type:Journal Article
- Keywords:
Lipoproteins,LDL;
Phospholipases A2;
Carotid artery diseases;
Atherosclerosis' Stroke;
Brain ischemia;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2010;18(4):282-285
- CountryChina
- Language:Chinese
-
Abstract:
The lipoprotein-associated phospholipase A2 (Lp-PLA2), a subtype of the phospholipase A2 superfamily, is produced primarily by macrophages and lymphocytes. Lp-PLA2specifically hydrolyzes oxidized phospholipids on oxidized low-density lipoprotein particles,resulting in production of lysophosphatidylcholine and oxidized fatty acids. Lp-PLA2 is expressed in atherosclerotic plaques and in macrophages within a fibrous cap of unstable plaque.Studies haw shown that the plasma Lp-PLA2 activity increases significantly in patients with ischemic stroke, and Lp-PLA2 may become an independent risk factor for predicting ischemic cerebrovascular events. The selective Lp-PLA2 inhibitor can reduce the inflammatory response,enhance the stability of plaques, and inhibit the formation of atherosclerotic plaques, and may become a new class of drugs for preventing the formation of atherosclerotic plaques.
