PI3K/AKT signal transduction pathway in GISTs
10.3760/cma.j.issn.1007-631X.2010.04.020
- VernacularTitle:磷脂酰肌醇3-激酶信号转导通路在胃肠道间质瘤中的表达及其意义
- Author:
Yi ZHAO
;
Qiang WANG
;
Ying ZHAO
;
Xin DENG
;
Tianbiao ZHANG
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
1-phosphatidylinositol 3-kinase;
Signal transduetion;
Apoptosis
- From:
Chinese Journal of General Surgery
2010;25(4):326-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of PI3K/AKT signal transduetion pathway in gastrointestinal stromal tumors(GIST).Methods The expression of PI3K、Akt、PTEN were detected with RT-PCR and Westem-blot of tumor specimens from 124 GIST cases and the corresponding normal gastric mucosa.Results In gastrointestinal stromal tumors,the tumor suppressor gene-PTEN was on low expression as with the inereased expression of PI3K and Akt.The positive expression rate of PTEN,PI3K and Akt was not statistically correlated with patients'demographics and tumor histological type,but they are significantly correlated with lymphatic metastasis and mucosal invasion.The expression of PI3 K and Akt are of significantly positive correlation(r=0.292,P=0.031).The expression of PI3K and PTEN are of significantly negetive correlation(r=-0.412,P=0.036).The expression of PTEN and Akt are of significantly negetive correlation(r=-0.386,P=0.024).Conclusion PI3 K/Akt and P,PTEN may have bean on reciprocally suppressive effect during the development of GIST.
