Effects of perinatal exposure to bisphenol A on learning and memory behavior of male F1 generation in rats
10.3760/cma.j.issn.1674-6554.2010.04.007
- VernacularTitle:围生期双酚A暴露对雄性子代大鼠学习记忆能力的影响
- Author:
Zhen LI
;
Gongliang ZHANG
;
Binsheng WANG
;
Jin ZHANG
;
Dehu KONG
;
Liecheng WANG
- Publication Type:Journal Article
- Keywords:
Bisphenol A;
Long-term potentiation;
Cerebral development;
Learning and memory
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(4):309-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of bisphenol A(BPA)exposure to perinatal on learning and memory behaviour in F1 generation male rats.Methods From the 11th day of gestation to the 7th day of field test was used to detect the locomotion activity,the Morris water maze was employed to measure learning and memory ability and long-term potentiation(LTP)were recorded to detect the synaptic plasticity in hippocampus CA1 with extracellular recording.Results The crossing number of BPA group(70.35±13.56)was much more than control group((29.32±14.12),P＜0.05).The number of standing up and ornament of BPA group((38.52±6.52),(6.26±2.78))were both higher than control group((10.35±8.38),(2.67±1.46),P＜0.05).BPA rats had longer escape latencies to find platform((55.22±5.78)s)than control rats((21.22±2.65)s,P＜0.05).Conditional protocol with high-frequency stimulation evoked a stable LTP in hippocampus CA1 region in control rats((162.13±10.12)%),however the LTP could not be induced with the same conditional protocol in BPA-exposed rats((101.05±7.58)%,P＜0.05).Conclusion Perinatal BPA exposure impaires learning and memory ability in F1 generation male rats related to presynaptic dysfunction.
