Recent advances in the study of correlationship link between microRNAs and p53
10.3760/cma.j.issn.1673-422X.2010.03.001
- VernacularTitle:微RNA与p53调控的关系研究进展
- Author:
Kun WANG
- Publication Type:Journal Article
- Keywords:
microRNA;
Genes,p53;
Neoplasms
- From:
Journal of International Oncology
2010;37(3):163-166
- CountryChina
- Language:Chinese
-
Abstract:
microRNA(miRNA) ,a class of small noncoding RNAs,negatively regulates gene expression at post-transcriptional level, and is involved in many fundamental biological processes, including development,apoptosis and cell proliferation, p53 is a transcription factor that plays a critical role in the control of cell cycle and apoptosis. Aberrant expression of either miRNA or p53 intimately links to tumorigenesis. This article reviews recent advances in the study of inter-relatioship between miRNA and p53 in tumorigenesis.
