Hymethylation of tumor suppressor genes and nasopharyngeal carcinoma
10.3760/cma.j.issn.1673-422X.2010.03.014
- VernacularTitle:抑癌基因高甲基化与鼻咽癌
- Author:
Xiongzhou SHI
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Genes;
Methylation
- From:
Journal of International Oncology
2010;37(3):204-206
- CountryChina
- Language:Chinese
-
Abstract:
Promoter CpG hymethylation is a major epigenetic mechanism to inactivate the functions of tumor suppressor genes(TSG),in addition to genetic mechanism(point mutation and deletion).The hymethylation in some genes is strongly associated with nasopharyngeal carcinoma(NPC).TSG methylation status examination is clinically significant,and could serve as a new technique for the early diagnosis of cancer,while reversing the methylation of TSG is a promising idea for cancer therapy.
