Treatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy.
10.14701/kjhbps.2011.15.3.152
- Author:
Suzy KIM
1
;
Kyubo KIM
;
Eui Kyu CHIE
;
Sun Whe KIM
;
Yung Jue BANG
;
Sung Whan HA
Author Information
1. Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea. swha@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Gallbladder cancer;
Surgery;
Radiotherapy;
Prognosis
- MeSH:
Disease-Free Survival;
Female;
Follow-Up Studies;
Gallbladder;
Gallbladder Neoplasms;
Humans;
Joints;
Prognosis;
Recurrence;
Retrospective Studies;
Survival Rate
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2011;15(3):152-156
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUNDS/AIMS: To investigate survival rates and prognostic factors of patients with gallbladder cancer who were treated with surgery and postoperative radiation therapy. METHODS: Seventeen gallbladder cancer patients who received surgery and postoperative radiotherapy from October 1989 to April 1998 were included in this retrospective study. Five patients had stage II, 8 patients had stage III, and 4 patients had stage IV disease according to the 1997 American Joint Committee on Cancer (AJCC) staging. All patients received > or =40 Gy of postoperative radiotherapy with a daily dose of 2.0 Gy/fraction and 15 patients received concurrent chemotherapy. An analysis was performed for the endpoints of overall and disease-free survival. RESULTS: Of the 17 patients, 13 had no residual disease (R0), 1 had microscopic residual disease (R1), and 3 had macroscopic residual disease (R2) after surgery. Among patients with no residual disease, 4 had locoregional recurrences during the follow-up period. One patient with microscopic residual disease had local recurrence. The 5-year overall survival rate was 38.2%. The median overall survival time was 21 months and the median disease-free survival time was 12 months. Old age (> or =60 years old), female gender, a high pathological stage (> or =IVA), and the presence of residual disease after surgery were significant prognostic factors for disease-free survival. CONCLUSIONS: Despite a high proportion of patients with advanced disease and macroscopic residual disease, the prognosis of gallbladder patients who had postoperative radiotherapy is encouraging. Additional investigation to improve the loco-regional control of gallbladder cancer patients with adverse prognostic factors is warranted.
