Regional blood perfusion, metabolism and angiogenesis of breast cancer
10.3760/cma.j.issn.1007-631X.2010.04.014
- VernacularTitle:乳腺癌区域血流灌注和代谢与血管生成的关系
- Author:
Chenggang WANG
;
Yu AI
;
Zhigang YU
;
Rong MA
;
Qinghui ZHANG
;
Shuwei LIU
;
Jingzhong SUN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Tomography,spiral computed;
Tomography,Emission computed;
Angiogenesis
- From:
Chinese Journal of General Surgery
2010;25(4):309-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the correlation between regional blood perfusion,metabolism and angiogenesis in breast cancer.Methods The PET/CT functional imaging technique was applied to quantitatively detect the central and marginal blood perfusion parameters including blood flow(BF),blood volume(BV)and permeability of surface(Ps),and metabolism index of standard uptake value(SUV)of the tumor in 33 breast cancer patients.The expression of CD31.CD105 and VEGF in paraffin section of breast cancer were detected by immunohistochemical method,then MVD(CD31)and MVD(CD105)were obtained.The relationship between the regional blood perfusion and metabolism and MVD(CD3 1),MVD(CD105)and the expression of VEGF were analyzed. Results There was significant correlation of MVD (CD31)with BF of marginal region(P<0.05).There were significant correlations of MVD(CD105)with BF.PS and SUV(P<0.05). Conclusions Regional blood perfusion,metabolism is correlated with angiogenesis in breast cancer tissue.PETT/CT regional blood perfusion and metabolic imaging iS a noninvasive method which can be used to estimate angiogenesis status clinically in breast cancer.
