Progress in the pathogenesis of rotavirus-associated disease
10.3760/cma.j.issn.1673-4408.2010.03.003
- VernacularTitle:轮状病毒感染发病机制的研究进展
- Author:
Ling ZHOU
- Publication Type:Journal Article
- Keywords:
Rotavirus;
Infantile diarrhea;
Viremia
- From:
International Journal of Pediatrics
2010;37(3):232-234
- CountryChina
- Language:Chinese
-
Abstract:
Rotavirus is the most common pathogens of diarrheal diseases in children. Rotavirus infection lead to not only gastrointestinal symptoms but also a variety of extraintesu'nal manifestations. The pathogenesis of RV diarrhea and especially RV viremia is related to multiple factors. Rotavirus infectious diarrhea is related to the damaged cell intercellular connections,the non-structural protein 4, heat shock protein hsc70 and other factors. Pathogenesis of RV viremia may be related to the secretion of inflammatory mediators in vivo and expression of cytokines after RV infection.
