Dendritic cell vaccine immunotherapy for patients with colorectal cancer

VernacularTitle:结肠癌术后联合树突状细胞免疫治疗的临床研究
Author: Chun ZHANG ; Guoqiang Lü ; Jianmin XU ; Chuanqing BAO ; Binghua XU ; Qiaxian WEN ; Xiao LU
Publication Type:Journal Article
Keywords: Colorectal neoplasms; Dendritic cells; Immunotherapy; Cytokines
From: Chinese Journal of General Surgery 2010;25(5):357-359
CountryChina
Language:Chinese
Abstract: Objective To evaluate dendritic cell vaccine immunotherapy in postoperative colorectal cancer patients. Methods 40 colorectal cancer patients were divided into two groups. Group A was not treated with the dendritic cell vaccine after chemotherapy, Group B was treated with four courses of autologous dendritic cell vaccine. The level of cytokines was tested before and after the therapy in both groups. DTH were tested after the last course of treatment. Results The levels of cytokines significantly increased in group B after vaccination compared with that in group B before vaccination and that in group A.8 patients were DTH positive in 15 patients that were tested after the vaccination. The PTS (progression-free survival) was 22 months in group B compared with 17 months in group A. The recurrence of the disease was not observed in patients with DTH positive. Conclusion DC vaccine in postoperative colorectal cancer patients improves the immune status and elicits tumor-specific response.