Exspression of STAT3, VEGF and survivin in gastric carcinoma
10.3760/cma.j.issn.1007-631X.2010.05.015
- VernacularTitle:信号传导与转录活化因子3、血管内皮生长因子和Survivin在胃癌组织中的表达及其临床意义
- Author:
Xiangyu LIU
;
Jingyu DENG
;
Lin ZHANG
;
Han LIANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Singal transduction;
Vascular endothelial growth factors;
Tumor markers;
Pathology,clinical;
Apoptosis
- From:
Chinese Journal of General Surgery
2010;25(5):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of STAT3, VEGF and Survivin in human gastric carcinoma and its clinicopathological significance. Methods The expression of STAT3, VEGF, survivin was determined by immunohistochemical staining of specimens from 53 cases undergoing radical gastrectomy and 53 cases of normal gastric mucous membranae. We evaluated the relationship between expression of these proteins and various clinicopothological factors. Results The expression rate of STAT3, VEGF and survivin in 53 gastric carcinoma tissues was 58%, 62% and 74%, respectively, which was significantly higher than those in the normal group(P <0. 01). STAT3 expression correlated with VEGF(r =0. 608 ,P <0. 01) ,survivin(r = 0. 451, P = 0. 001). Positive STAT3, VEGF staining was significantly associated with tumor size, Lauren's classification,lymph node metastasis and clinical staging(P < 0. 05). Survivin staining was significantly associated with Lauren's classification, lymph node metastasis and clinical staging(P <0. 05). Multivariate analysis revealed STAT3 expression and lymph node metastasis were independently prognostic factors of poor survival. Conclusion VEGF, survivin possibly regulated by STAT3 leads to tumor angiogenesis and anti-apoptosis. The expression of STAT3 is an independent prognostic factors in gastric carcinoma.
