mRNA expressions of chemerin and its receptor 1 in adipose tissue of OLETF rats
10.3760/cma.j.issn.1000-6699.2010.05.020
- VernacularTitle:OLETF大鼠脂肪组织chemerin及其受体1的基因表达
- Author:
Bing LI
;
Juhong YANG
;
Nan WANG
;
Dongchun LIANG
;
Changxin JIANG
;
Ping FENG
- Publication Type:Journal Article
- Keywords:
OLETF;
Chemerin;
CMKLR1;
Real-time PCR;
Gene expression
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(5):413-415
- CountryChina
- Language:Chinese
-
Abstract:
The mRNA expressions of chemerin and its receptor CMKLR1 in adipose tissue of OLETF rats and LETO rats were detected by real-time PCR. The results showed that the two genes mRNA expressions in subcutaneous and visceral adipose tissue in OLETF group were significantly higher than those in LETO group (P< 0.05 or P<0.01) and expressions of them in visceral adipose tissue were higher than those in subcutaneous adipose tissue(P<0. 05 or P<0. 01), suggesting that chemerin and CMKLR1 may be involved in the pathogenesis of obesity, insulin resistance, and type 2 diabetes mellitus.
