Expression and significance of EMMPRIN and VEGF-C of breast carcinoma
10.3760/cma.j.issn.1008-1372.2010.04.014
- VernacularTitle:细胞外基质金属蛋白酶诱导因子和血管内皮生成因子-C在乳腺癌的表达及其意义
- Author:
Yunxia LIANG
;
Maohuai CHEN
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases/ME;
Vascular endothelial growth factor C/ME;
Breast neoplasms/ME
- From:
Journal of Chinese Physician
2010;12(4):470-473
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of EMMPRIN and VEGF-C expression with invasion and metastasis of breast carcinoma. Method The expression of EMMPRIN and VEGF-C was detected by immunohistochemical technique in 21 cases hyperplasia of mammary glands, 10 cases of in-tubule carcinoma and 68 cases invasive carcinoma. Results The positive rate of EMMPRIN expression in hyperplasia of mammary glands, in-tubule carcinoma and invasive carcinoma were 4. 76% (1/21), 40. 00% (4/10)73.53% (50/68), respectively;Significant difference was found among three groups ( P < 0.01 ). The positive rate of VEGF-C expression in hyperplasia, in-tubule carcinoma and invasive carcinoma were14. 29% (3/21) ,60. 00 (6/10) ,77.94% (53/68), respectively. The positive rates of VEGF-C expression in situ and invasive ductal carcinoma were remarkably higher than that of hyperplasia of mammary glands ( P <0. 01 ). The expression of EMMPRIN significantly correlated with the expression of VEGF-C in breast tubule carcinoma ( rs =0. 390, P <0. 01 ), Lymph nod metastasis and the number axillary Lymph nod metastasis were related to EMMPRIN and VEGF-C ( P < 0. 01 ). Conclusion The over-expression of EMMPRIN and VEGF-C were important elements to promote the invasiveness and metastasis of breast carcinoma. Synergistic effect between EMMPRIN and VEGF-C may take place in lymph node metastasis of breast carcinoma.
