5-HT3 receptors and irritable bowel syndrome
10.3760/cma.j.issn.1673-4408.2010.03.021
- VernacularTitle:5-HT3受体与肠易激综合征
- Author:
Fan YANG
- Publication Type:Journal Article
- Keywords:
Serotonin;
5-HT3 receptors;
5-HT3 receptor antagonist;
Irritable bowel syndrome
- From:
International Journal of Pediatrics
2010;37(3):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Serotonin and its receptors exist extensively in gut,5-HT3 receptor is ligand-gated ion channel.It is composed of five subunits,S-HT3A ,5-HT3B ,5-HT3C ,5-HT3D and 5-HT3E .The genetics of serotonin receptors appear to be associated with irritable bowel syndrome.5-HTTLPR genetic polymorphisms influence the efficacy of serotonergic treatments. As a new generation of developed 5-HT3 receptor antagonists, alosetron and ramosetron act an important role in regulating gastrointestinal motility and visceral perception. They are efficacious in the treatment of irritable bowel syndrome. Ramosetron show high affinity for 5-HT3 receptors,dissociate slowly from 5-HT3 receptors and show long-lasting 5-HT3, receptor antagonism.
