Tendency of dyslipidemia in the early stage after renal transplantation: multicenter investigation in Beijing region
10.3760/cma.j.issn.0254-1785.2010.05.004
- VernacularTitle:肾移植受者术后早期血脂异常的趋势——北京地区多中心调查分析
- Author:
Linlin MA
;
Jianhua AO
;
Lulin MA
;
Ming CAI
;
Xuren XIAO
;
Zhihao YANG
;
Xingke QU
;
Zhigang JI
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Lipid metabolism disorders;
Cholesterol;
Cholesterol
- From:
Chinese Journal of Organ Transplantation
2010;31(5):269-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the current dyslipidemia profiles and correlation with etiological factors in early stage post-transplantation, and the impact of lipid metabolic disorder on renal function. Methods The clinical data of 1032 renal allografts from eight hospitals in Beijing between 2004 and 2008 were collected and evaluated retrospectively. Before and at the 1st, 3rd, 6th and 12th month post-transplantation, the changes in blood total cholesterol (TC), triglycerides (TG),low density lipoprotein (LDL)-cholesterol and high density lipoprotein (HDL)-cholesterol were analyzed. The difference in the blood lipid disorder at different stages stratified by time and different age group, the effects of immunosuppressive agents on blood lipid, and the impact of blood lipid disorder on the blood creatinine were studied. Results Except HDL-cholesterol, TC, LDL-cholesterol and TG levels were increased gradually at the first year, especially LDL-cholesterol and TG. The TC and LDL-choleaterol abnormalities were obviously related with age (P<0. 01 ). The effect of Tacrolimus (Tac)-based immunosuppressive regimen on the lipid metabolic disorder was less than cyclosporine (CsA). At the first year, there was no significant difference in blood creatinine between lipid-lowering treatment and non-lipid-lowering treatment (P>0. 05). For the recipients not subject to lipid-lowering treatment and their TG level higher than the normal at the first month after operation, the creatinine level at the first year was significantly higher than in those with normal TG level (P< 0. 05). Conclusion The lipid metabolic disorder following renal transplantation is a common complication after the first transplant year, and was related with age and immunosuppressive agent regimen. Tac-based immunosuppressive regimen has little effects on the blood lipid metabolism.
