The roles of hypoxia-inducible factor-1 in ischemic brain injury
10.3760/cma.j.issn.1673-4165.2010.04.013
- VernacularTitle:缺氧诱导因子-1在缺血性脑损伤中的作用
- Author:
Tuo CAI
;
Yanfang ZHOU
;
Yubin DENG
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor 1;
Brain ischemia;
Brain injury
- From:
International Journal of Cerebrovascular Diseases
2010;18(4):300-305
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1 (HIF-1), as a nuclear transcription regulator of the hypoxic response, is up-regulated during hypoxia, and it regulates a series of downstream target gene expression, such as vascular endothelial growth factor, glucose transporter and erythropoietin through binding with hypoxia response element. It plays important roles in angiogenesis, anerobic metabolism, cell survival, proliferation, migration, and differentiation.This article reviews the structure, function and activity regulation of HIF-1 and its roles in acute ischemic brain injury.
