N-methyl-D-aspartate receptor NR2B subunit and neuronal apoptosis
10.3760/cma.j.issn.1673-4165.2010.04.014
- VernacularTitle:N-甲基-D-天冬氨酸受体NR2B亚基与神经元凋亡
- Author:
Yanping WANG
;
Jinsheng YANG
- Publication Type:Journal Article
- Keywords:
Receptors,iV-methyl-D-aspartate;
Protein subunits;
NR2B NMDA receptor;
Apoptosis;
Neurons;
Neuroprotective agents
- From:
International Journal of Cerebrovascular Diseases
2010;18(4):306-310
- CountryChina
- Language:Chinese
-
Abstract:
Neuronal apoptosis is one of the important forms of neuronal death in ischemic stroke.N-methyl-D-aspartate (NMDA) receptor-mediated excitatory amino acid toxicity plays an important role in neuronal apoptosis. It is the initiator and executor of apoptosis in neuronal cells. NR2B is the major regulatory subunit of this receptor, its transmembrane segment M2 is a reflexed membrane loop region facing cytoplast toward intramembrane, forming the inner wall of ion channel, which determines the permeability of the NMDA receptor ion channel to calcium. Glutamate mediates cell injury mainly through calcium overload, therefore, NR2B subunit plays a vital role in the neuronal apoptosis in ischemic stroke.
