Costimulatory molecules CD28-B7 family and clinical diseases
10.3760/cma.j.issn.1673-4408.2010.03.011
- VernacularTitle:共刺激分子CD28-B7家族与临床疾病
- Author:
Na YANG
- Publication Type:Journal Article
- Keywords:
Costimulatory signals;
CD28/CTLA4-B7;
ICOS-ICOSL/B7-H2
- From:
International Journal of Pediatrics
2010;37(3):254-257
- CountryChina
- Language:Chinese
-
Abstract:
The CD28-B7 are members of immunoglobulin superfamily.When B7 is engated by the CD28 ligand, a costimulatory signal occurs and transfers to T cell and it is important in the activation, proliferation, anti-apoptosis and promoting cytokine secretion of T cell.The CD28-B7 family is associated with tumor and autoimmune disease.
