Histological evaluation on preoperative regional intraarterial chemotherapy for colorectal carcinoma
10.3760/cma.j.issn.1007-631X.2010.05.003
- VernacularTitle:结直肠癌术前区域动脉灌注化疗疗效的组织学评价
- Author:
Zefeng XIA
;
Ye YUAN
;
Kaixiong TAO
;
Gaoxiong HAN
;
Xiaoming SHUAI
;
Kailin CAI
;
Jiliang WANG
;
Hansong DU
;
Meizhou DENG
;
Guobin WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Chemotherapy,cancer,regional perfusion;
Histology
- From:
Chinese Journal of General Surgery
2010;25(5):353-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the histological response and the clinical value in laparescopic colorectal surgery combined with preoperative regional intra-arterial chemotherapy(PRAC). Methods In cases of rectal cancer and fiver metastases selective regional intra-arterial chemotherapy and iodinated oil embolism was carried out in 23 cases of colorectal carcinoma. After 1 to 11 days laparoseopic radical resection was done, specimens were sent for histopathological examination. We analyzed the correlation between tumor differentiation and TNM stage, compared the effect of PRAC with PRAC + embolism by the criteria of histological response of chemotherapy. χ2-test was used to compare interclass correlation.Results The histological effect in the 23 cases of PRAC level 0 was in 2 cases, level Ⅰ in 7 cases, level Ⅱ in 10 cases, and level Ⅲ in 2 cases. The overall effective rate was 91% (21/23). In the 15 cases with lymph node metastases, the effective rate was 87% (13/15). There was no significant statistic correlation between tumor differentiation or TNM stage and histological response. PRAC associated embolism had a better histological response compared to PRAC alone. Conclusions Preoperative regional intra-arterial chemotherapy had marked therapeutic effect on histological response to the colorectal carcinoma patients of various tumor differentiations and TNM stage, especially combining with the embolism to rectal cancer could improve the efficacy.
