Expression of SDF-1/CXCR4 in patients with acute rejection after liver transplantation
10.3760/cma.j.issn.1007-8118.2010.05.016
- VernacularTitle:SDF-1/CXCR4在肝移植急性排斥反应中的表达
- Author:
Xingchu MENG
;
Wei GAO
;
Yanjun LI
;
Yang LI
;
Cheng PAN
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
CXCR4;
Acute rejection
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(5):366-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the principle of chemokine stromal-dirived factors-1(SDF-1)in acute rejection,we test the expression of CXCR4 which is the receptor of SDF-1 in acute rejection following liver transplantation. Methods needle-biopsy specimens after liver transplantation were divided into four groups according to Banff schema.We analyzed the mRNA level of CXCR4 in each group by RT-PCR.Results In non-rejection group and control group,all samples expressed CXCR4 in small and medium dose.In rejection group,high level expression of CXCR4 related to high degree of acute rejection were found.Conclusion The CXCR4 plays an important role in acute allograft rejection of human liver after transplantation.To restrain the expression of CXCR4 may be au effective method of anti-acute rejection.
