Extrahepatic recurrence after curative resection of hepatocellular cancer
10.3760/cma.j.issn.1007-631X.2010.05.009
- VernacularTitle:原发性肝细胞癌根治性切除术后肝外复发的危险因素分析
- Author:
Yanming ZHOU
;
Jiamei YANG
;
Bin LI
;
Zhengfeng YIN
;
Feng XU
;
Tong KAN
;
Feng XIE
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Risk factors;
Neoplasms recurrence,local
- From:
Chinese Journal of General Surgery
2010;25(5):370-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of extrahepatie recurrences after curative resection of primary hepatocellular carcinoma (HCC). Methods Clinicopathologic data of 238 curative resected cases of primary HCC were retrospectively reviewed for parameters affecting postoperative extrahepatic recurrences. Results During a median follow-up of 34 months (7 - 78 months), extrahepatic recurrences were observed in 32 out of 238 patients (13.4%). According to univariate analysis, the risk factors for extrahepatic recurrences were preoperative serum a-fetoprotein (AFP) level of > 1000 ng/ml,aspartate aminotransferase level of > 50 IU/L, presence of hepatic vein invasion, neighboring organ invasion, tumor satellites, and lack of tumor capsule formation. Preoperative serum AFP levels of > 1000 ng/ml, hepatic vein invasion, neighboring organ invasion proved to be independent risk factors by multivariate analysis. Conclusions Extrahepatic recurrences after curative resection of HCC was found to be related to preoperative serum AFP level of > 1000 ng/ml, hepatic vein invasion, and neighboring organ invasion.
