Clinical and pathological characteristics of IgA nephrology secondary to primary Sj(o)gren's syndrome

VernacularTitle:继发于原发性干燥综合征的IgA肾病临床病理分析
Author: Jing CHEN ; Yizhi CHEN ; Xuezhi ZHAO ; Yong CUI
Publication Type:Journal Article
Keywords: Sj(o)gren's syndrome; Glomerulonephritis,IgA; Characteristic of clinicopathologic
From: Chinese Journal of Rheumatology 2010;14(5):329-331
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical and pathologieal characteristics of IgA nephmlogy secondary to primary sj(o)gren's syndrome(pSS).Method The clinical and pathological data of 8 patients with pSS and IgA in Changzheng Hospital from 2004 to 2009 were analyzed.Results The average age of seven female and one male was (44±8) years old.Five patients presented with edema and proteinuria.Eight patients presented with microhematuria.The average 24-hour proteinuria was (3±4) g.Two patients had hypertension.Serum creatinine levels of two patients were higher than normal level,the others'were normal.Light microscopy examination showed three patients were mild mesangial proliferation with Lee's classification grade Ⅰ;five patients had global sclerosis with Lee's classification grade Ⅱ,Ⅲ and Ⅳ.Positive IgA was mainly found under immunofluorescence microscopy.Electronic microscopy showed no electron-dense deposits.Conclusion IgA nephrology secondary to pSS is different from primary IgA nephrology under immunofluorescence microscopy.