Protective effect of cocaine-and amphetamine-regulated transcript peptide in ischemic brain injury
10.3760/cma.j.issn.1673-4165.2010.03.012
- VernacularTitle:可卡因-苯丙胺调节转录肽在缺血性脑损伤中的保护作用
- Author:
Jiali JIN
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Neuropeptides;
Neurons;
Brain ischemia;
Neuroprotective agents;
Cocaineand amphetamine-regulated transcript protein
- From:
International Journal of Cerebrovascular Diseases
2010;18(4):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Cocaine-and amphetamine-regulated transcript (CART), an endogenous neuropeptide, is widely distributed in human organs and tissues, such as brain, gastrointestinal tract and pancreas. It has a variety of important physiological functions, including eating and obesity, stress, mental anxiety, drug addition, and endocrine regulation. Previous studies have suggested that CART is widely distributed in the central nervous system, and it involves in the regulation of a variety of physiological processes and has some central protective effects. It is a potential neuroprotective agent. This article reviews the recent progress in research on the neuroprotective effect of CART on stroke and neurodegenerative disease and its mechanisms, as well as its therapeutic effect in central nervous system diseases.
