Comparison of different regimens in treatment of depressive disorder in diabetic patients with nephropathy
10.3760/cma.j.issn.1671-7368.2010.05.021
- VernacularTitle:糖尿病肾病患者伴发抑郁症状综合治疗的临床观察
- Author:
Yu WANG
;
Yan ZHANG
;
Dongmei WANG
;
Jingqiu CUI
;
Xiaojun REN
;
Ping FENG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Depression
- From:
Chinese Journal of General Practitioners
2010;9(5):340-342
- CountryChina
- Language:Chinese
-
Abstract:
Two hundred and four patients with diabetic nephropathy and depressive disorder were randomly assigned to the control group (40 cases), St.John's Wort extract (SWE) group(40 cases) ,SWE +psychotherapy group ( 40 cases), SWE + physicotherapy group ( 40 cases ) and SWE + psychotherapy +physicotherapy group (44 cases), all patients were treated for 12 weeks.The therapeutic effects were evaluated with Hamilton Rating Scale for Depression-17 (HAMD-17).The percentage reduction in HAMD scores in SWE + psychotherapy + physicotherapy group was the highest ( 86% ), and those for SWE, SWE +psychotherapy, SWE + physicotherapy and control groups were 47%, 55%, 60% and 13%, respectively (x2 =47.331, P =0.000).After 12 weeks of treatment, glycosylated hemoglobin(HbA1c) and urinary albumin excretion rate (UAER) were reduced in all 4 treatment groups compared with the control group.The levels of HbA1 c and UAER in SWE + psychotherapy + physicotherapy group were significantly lower than those in others ( F = 15.754,74.025, all P = 0.000).St.John' s Wort extract with psychotherapy and physicotherapy can efficiently improve the depressive disorder in type 2 diabetic patients with nephropathy, as well as control blood glucose and reduce UAER of patients.
