Progress of genome-wide association studies in type 2 diabetes mellitus

VernacularTitle:2型糖尿病全基因组关联分析的研究进展
Author: Qiong HUANG ; Jiye YIN ; Zhaoqian LIU
Publication Type:Journal Article
Keywords: Genome-wide association study; Diabetes mellitus,type 2; Polymorphism,single nucleotide; Islet β-cells; Gene region
From: Chinese Journal of Endocrinology and Metabolism 2010;26(5):432-436
CountryChina
Language:Chinese
Abstract: Genome-wide association studies ( CWAS) use high-throughout genotyping technologies to investigate the relation of hundreds of thousands of gene markers(genotype) with clinical conditions and measurable traits (phenotype). Type 2 diabetes mellitus results from the interaction of environmental factors with genetic variants. Many progresses have been acquired from GWAS. New gene regions have been discovered to be involved in the development and function of islet (3-cells, which provides new strategies for the etiology investigation, prevention, and treatment of type 2 diabetes mellitus.