Expression of serum gangliosides and its significance in patients with gastric cancer

VernacularTitle:神经节苷酯GM1、GM3在胃癌患者血清中的表达及意义
Author: Ming YANG ; Dan LONG
Publication Type:Journal Article
Keywords: Gangliosides/BL; Stomach neoplasms/BL
From: Journal of Chinese Physician 2010;12(5):612-614
CountryChina
Language:Chinese
Abstract: Objective To study the level of serum gangliosides ( GM1 and GM3) in patients with gastric cancer and its clinical significance. Methods The ELISA (Enzyme-linked Immunosorbnent Assay, ELISA) method was used to detect GM1 and GM3 content in 40 patients with gastric cancer, and healthy controls. The results were analyzed with statistic software. Results The levels of serum GLS of gastric cancer group were significantly higher than that in healthy group and those in healthy subjects [(815.53±75.56)ng/ml vs (88. 88±32. 73)ng/ml;(765. 92 ±61.09)ng/ml vs (28.03±9.64) ng/ml, P <0.01 ] , patients with gastric cancer after chemotherapy and surgery group, and serum GLS was different between the healthy group and those in healthy subjects, patients with liver cancer after chemotherapy and surgery group. There was positive correlation between GM1 and GM3( r =0. 24, P <0.05).Conclusion Serum GLS of the patients with gastric cancer increased remarkably. Combined detection of serum gangliosides content in gastric cancer will be helpful to diagnosis of gastric cancer,disease progress prediction,and relapse prediction of this disease.