Expression and clinical significance of ADAM-12 and PCNA in bladder carcinoma
10.3760/cma.j.issn.1008-6315.2010.05.027
- VernacularTitle:去整合素金属蛋白酶-12和增殖细胞核抗原在膀胱癌组织中的表达及临床意义
- Author:
Weilong QU
;
Laikun TANG
;
Feng TIAN
;
Zulin WANG
;
Li SONG
;
Zhongwei YU
;
Qing YE
;
Ke WANG
;
Fengjin WU
;
Dexing LUO
- Publication Type:Journal Article
- Keywords:
Bladder carcinoma;
Adamalysin-12;
PCNA;
Immunohistochemistry
- From:
Clinical Medicine of China
2010;26(5):524-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of adamalysin-12 (ADAM-12) and PCNA in human bladder carcinoma and to investigate their correlation with different grades and stages of bladder cancer.Methods Biopsies of 15 normal bladder and 43 bladder tumors were analyzed.Immunohistochemistry was conducted to detect the expression of ADAM12 and PCNA in the biopsies.Results Postive expression signals of ADAM12 were detected significantly higher in the bladder cancer biopsies than that in the normal ones (P = 0.010).Those with lower histological grade had a higher expression level of ADAM-12 compared to the higher histological grades (P ＜0.001 ).Positive expression signals of PCNA were detected significantly higher in the bladder cancer biopsies than that in the normal ones (P = 0.026).Those with lower histological grade had a higher expression level of PCNA (P =0.014).There was a positive correlation between the expression of ADAM-12 and PCNA in bladder cancer (r =0.997,P ＜ 0.001 ).Conclusions The overexpression of ADAM-12 and PCNA in the biopsies of bladder tumors shows that protein expression of ADAM-12 and PCNA correlated with tumor stage and grade.Furthermore,ADAM-12 may be a promising biomarker of bladder cancer in the clinical implication.
