Diagnosis and treatment of Sj(o)gren's syndrome with severe ostalgia as the main clinical manifestation

VernacularTitle:严重骨痛为主要临床表现的干燥综合征患者的诊治
Author: Chenlin DAI ; Hongwei JIA ; Hongyan WEI ; Mingcai QIU
Publication Type:Journal Article
Keywords: Sj(o)gren's syndrome; Ostalgia; Muscle biopsy; Hyperinsulinemia
From: Chinese Journal of Endocrinology and Metabolism 2010;26(5):388-390
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical characteristics of five Sj(o)gren's syndrome (SS) patients with severe ostalgia. Methods Five SS patients from the endocrinology department of our hospital were retrospectively analyzed. Results All the patients were female, with 9.5 year average course of disease, obvious ostalgia, muscle weakness and complaint, limitation of activity, and different degree of exocrine gland impairment. All the patients had different degree of acidosis, disorders of calcium and phosphorus metabolism, and dyspoiesis of calcitriol. Among them, three patients were found to have hyperinsulinemia and muscle pathological changes detected by the biopsy. Conclusions System factors must be investigated when patients present the bone symptom. At the same time, muscle problem should not be neglected and the patients should be treated as an entirety.